Antonio Sebastiano Minturno (1500–1574) was an Italian poet and critic, and Bishop of Ugento.

In their castle of Genazzano he learned Greek from a certain maestro Paolo, and made some progress in Hebrew.

In order to escape the plague he left Rome in 1523 and returned to Sessa, where he studied mathematics, and thence to Naples.

The wars caused him to remove to Sicily, where the viceroy Monteleone welcomed him and granted him a pension of 200 ducats.

In 1559 he wrote the critical work De Poeta, a lengthy dialogue in which he maintains the Aristotelian idea of tragedy as a lesson to the audience on the transience of worldly things, and as a method of spiritual purgation.