In the beginning of the 2011–12 season, after playing two matches in the Europa League's third qualifying round against Swiss side FC Thun, he left Palermo, making a total of 122 appearances and scoring six goals during his tenure.

[6] Nocerino made his Milan debut in the first 2011–12 game of the season on 9 September 2011 coming on as a 68th-minute substitute for fellow debutante Alberto Aquilani in a 2–2 home draw against Lazio.

[8] On 15 October, he scored his first goal in the 3–0 home victory against former club Palermo, completing a great team move led by Antonio Cassano and Robinho.

Due to the injury crisis, he played regularly until picking up his fourth caution of the season on 6 November, resulting in a suspension.

[14][15] In the summer of 2012, Nocerino took the A.C. Milan squad number 8 following the departure of Gennaro Gattuso to join Swiss club Sion.

After the game, Nocerino told the press that he would like to dedicate his goal to the victims of the Sandy Hook Elementary School shooting.

"[17] However, as the season progressed, Nocerino considered leaving the club in the summer if he was not guaranteed a regular starting place.

[16] Following the sack of Manager Allegri, Nocerino made 11 appearances in 2013–14 season and reacted with shock when he left A.C. Milan on loan.

[20] On 25 January 2014, Nocerino signed for Premier League club West Ham United on loan for the remainder of the season.

[21] Nocerino made his first appearance for West Ham against Chelsea on 29 January coming on as a substitute for Kevin Nolan in the 80th minute in a 0–0 draw at Stamford Bridge.

[22] Having made ten appearances for the club, Nocernino's loan spell with West Ham United came to an end despite his wish to stay.

[32] He played in the quarter-finals against England, where he had a goal disallowed for offside in extra-time, and subsequently scored in the penalty shootout which Italy won 4–2.

[37] Nocerino was primarily known for his pace, stamina, strength, and his tenacious tackling ability, as well his adeptness at reading the game and pressing opponents.

He was also capable of being an offensive threat due to his tendency to make attacking runs into the box, as well as his eye for goal and powerful and accurate shot from distance.

[42] On 18 September 2007, it was reported that Nocerino was hit by a car after leaving a restaurant in Turin and was hospitalised for scans when he suffered minor concussion and bruising.

[43] In response of asking question to Twitter, Nocerino has two children that he cited "change his life and that his father is his role model.