His original trainers included Ignacio "Buck" Avila, Antonio Orozco Sr., Manuel Rios, Juan M. Aldana Jr. and Alfred Ritz.
On June 11, 2010, Orozco beat Mike Peralta by unanimous decision in San Diego.
[3] On September 14, 2018, fought for a world title for the first time in his career, against Jose Carlos Ramirez, for the WBC light welterweight belt.
Ramirez was also the more active fighter, especially towards the end of the fight, earning him the unanimous decision win over Orozco.
Both boxers had they say throughout the fight, but Orozco got the edge with his aggressiveness and boxing skills, en route to a unanimous decision win.