He was born in Salamanca, Spain in 1479 and seems to have settled in Rome, Italy, around 1510, when he married an Italian woman.

It has been recorded that he was an active book-seller at the Campo de' Fiori of Rome in 1517 and that his publishing house flourished in 1526.

In 1532 he published his first collection of engravings with prints of mythological interest, including works by Raphael.

His cooperation with Lafreri lasted until his death, for almost a decade, and produced engraved maps, prints and views of cities, as well as informative leaflets (avvisi) of important events of his time.

[1] After his death, in 1562, his son Francesco Salamanca continued the cooperation with Antonio Lafreri.