He started his career in 1964 playing for Aspida Xanthi before moving to Panathinaikos on 31 July 1968.

[1] Antoniadis scored his first official goal for Panathinaikos on 27 October 1968 in a 1–0 victory over Apollon Athens.

In 1971,when Panathinaikos reached the European Cup Final against Ajax, Antoniadis was the leading scorer in the tournament with 10 goals.

[3] During the summer of 1978 he was transferred to Olympiakos where he stayed for one season, playing in 13 games and scoring 7 goals.

He made 21 appearances and scored 6 goals for the Greece national team between 1970 and 1977.