Antwain Joquan Spann (born February 22, 1983) is an American former professional football safety.

Spann played football at El Camino High School in Oceanside, California.

In 2003, he transferred to the University of Louisiana at Lafayette, where he started 11 games at cornerback in his senior season in 2004, recording a team-high four interceptions.

Spann was waived by the team on September 2, 2006, and signed to the Patriots' practice squad the following day.

Spann was waived by the Patriots on July 27, 2009, after signing 2009 draft pick Patrick Chung.