The station opened on 1 March 1865[1][2] and currently serves railway lines 25, 27, 27A and 59.

The train services are operated by the National Railway Company of Belgium (NMBS/SNCB).

In 1983, when Berchem and Antwerp became one city, the station was renamed Antwerpen-Berchem.

International Thalys and Benelux services (from Amsterdam to Brussels and Paris) stopped calling at this station, following the opening of the North-South tunnel under Antwerpen-Centraal.

Bus services 20, 21, 30, 32, 38, 51, 52, 53, 90, 91, 92, 93, 298, 420, 421 and 422 serve the station, these are operated by De Lijn.