After Indonesian independence, Tjokroaminoto entered politics through the Masyumi Party, serving briefly as a minister before moving to PSII.

[8] During the Japanese occupation period, Tjokroaminoto worked at the Japanese-sponsored newspaper Asia Raya as deputy chief editor.

[4] According to Tan Malaka, during Tjokroaminoto's time at Asia Raya he wrote popular satirical articles portraying Japan's occupation in a negative light under the pen name "Bang Bedjat" (Mr Pervert).

[1] Later on, Tjokroaminoto joined a political liaison group of other nationalist youths led by his colleague at Asia Raya, B.M.

[11] He was then appointed to the "Army Political Education Staff" and was given a nominal rank of major general, despite having no military experience.

[4] He was later honorably discharged from his military assignment, and afterward, he returned to journalism for some time, managing the al-Djihad daily newspaper.

[14] Within the month, however, the APRA coup d'état led by Raymond Westerling rocked Jakarta, and the United States of Indonesia government immediately suspected the State of Pasundan's government as having supported Westerling, leading to the arrest of Tjokroaminoto and his cabinet and eventually the dissolution of Pasundan.

[16][17] In May 1953, due to political tensions between PSII and Wilopo in the aftermath of the 17 October Affair, Tjokroaminoto was withdrawn from the cabinet, and he was later replaced by R.P.