On 13 September 1894, the Holy See established the Apostolic Prefecture of Eritrea, then an Italian colony, with the decree Ut saluti animarum of the Congregation for the Propagation of the Faith.
Discontent among the Eritrean Catholics led to the sending in 1927 of the future cardinal Alexis Lépicier as an Apostolic Visitor to examine the situation.
As a result, Father Kidanè-Maryam Cassà was appointed at first Pro-Vicar Apostolic for the Ethiopic-Rite Catholics and then, on 4 July 1930, bishop in charge of an independent Ordinariate of Eritrea.
The Vicariate, which previously had under its jurisdiction the great majority of the Catholics in Eritrea, became less important numerically than the growing ordinariate, which on 31 October 1951 was raised to the level of an exarchate (the Eastern equivalent of a Vicariate) under the name of the Apostolic Exarchate of Asmara, and on 28 February 1961 became an eparchy, the Eastern equivalent of a diocese.
[8] When the fourth and last bishop who held the post of Vicar Apostolic of Eritrea or Asmara retired on 2 June 1974, no successor was appointed and the administration of the Vicariate was entrusted to a Capuchin priest.