The Apostolic Prefecture (or Prefecture Apostolic) of the Delta of the Nile (Latin: Praefectura Apostolica Deltae Nili) was a Latin Church missionary jurisdiction of the Catholic Church, situated in the north of khedival Egypt, comprising four of the six provinces forming Lower Egypt: Gharbieh, Charkieb, Menufieh and Kalyiubieh.
About this time the Egyptian capital Cairo, which had already outgrown its former limits, developed considerably on the north, and populous quarters grew up within the Prefecture of the Delta.
For the convenience of resident Catholics, a Latin Church parish was formed in the Choubra quarter in 1894 and given to the Fathers of the Society for African Missions; in 1896 another Latin parish under the same direction was established at Zeitoun for the outlying districts of Koubbeh, Zeitoun and Matarieh.
The Catholic Charitable Institutions were: 3 hospitals: 1 conducted by the Filles de la Charité, and 2 by the Pieuses Mères de la Nigritie (150 to 200 sick); 2 orphanages: 1 for boys, conducted by the Filles de la Charité (60 orphans), and 1 for girls by the Sisters of the Good Shepherd of Angers (78 orphans); 5 dispensaries in charge of the Sisters of Notre-Dame des Apôtres, where several hundreds of sick daily receive gratuitous treatment; I home for the aged conducted by the Filles de Notre-Dame des Douleurs where from 50 to 60 inmates, both men and women, are cared for gratuitously; 1 house of refuge in charge of the Sisters of the Good Shepherd of Angers.
The Prefecture of the Delta owed its development chiefly to the prodigious growth of the city of Cairo which, in extending its limits, had to stretch out upon prefectorial territory.