Established on 25 January 1886 as Apostolic Prefecture of the Delta of the Nile (Curiate Italian Delta del Nilo), on territory split off from the northern part of the Apostolic Vicariate of Egypt.
Augustin Duret was appointed Prefect Apostolic, and wrote an article about the Prefecture for the Catholic Encyclopedia.
[1] Promoted on 17 September 1909 as Apostolic Vicariate of the Nile Delta; Duret was named titular bishop of Bubastis.
On 30 November 1987, it was United with (i.e. merged in, yet remaining a title of) the Latin Apostolic Vicariate of Alexandria of Egypt.
Its former cathedral episcopal see, Our Lady of Heliopolis in that suburb of the Egyptian national capital Cairo, remains a Co-cathedral of the vicariate.