The Apostolic Vicariate of Jolo is a Latin Catholic missionary pre-diocesan jurisdiction that cover the Sulu and Tawi-Tawi provinces in southern Philippines.

It is directly exempt to the Holy See, specifically to the Roman Congregation for the Evangelization of Peoples, and is not part of any ecclesiastical province.

However, for the purpose of apostolic cooperation, it is sometimes grouped with the Archdiocese of Zamboanga.

Established on 28 October 1953 as Apostolic Prefecture of Sulu,[1] of territory split off from the then Territorial Prelature of Cotabato and Sulu (now Archdiocese of Cotabato).

Promoted and renamed after its see on 12 July 1958 as Apostolic Vicariate of Jolo, led by a titular bishop.