Its cathedral see, Catedral María Auxiliadora, is located in the town of Puerto Ayacucho, in Venezuela's Amazonas state.

It is immediately exempt to the Holy See and not part of any ecclesiastical province.

On 5 February 1932 Pope Pius XI established the Prefecture Apostolic of Alto Orinoco from territory taken from the then Diocese of Santo Tomás de Guayana (which meanwhile became the Metropolitan Archdiocese of Ciudad Bolívar).

It was elevated to a Vicariate Apostolic and given its present name by Pope Pius XII on 7 May 1953.

You can help Wikipedia by expanding it.This article on a Roman Catholic diocese in Venezuela is a stub.