[8] His father was Pietro Zeno,[9] a doctor of medicine, and his mother, Caterina Sevasto, belonged to an illustrious and powerful family from Candia, Crete.

He began work as a literary journalist for the Galleria di Minerva, also taking upon executive responsibilities, but distanced himself when he realized that he had not succeeded in making the impact upon the publication that he intended.

Adopting the approach of Tarcagnota's early seventeenth-century editors, later repeated by William Temple in 1695 for a History of England, Albrizzi assigned the new sections to a team of expert writers.

Unlike them, he followed the Renaissance humanists in discarding the awkward Christianized version of the Book of Daniel's four-monarchy scheme, which divided universal history into the periods of Babylon, Persia, Greece, and Rome, distantly succeeded by the kingdom of heaven.

He didn't treat the Holy Roman Empire as the logical extension of Rome into the modern world, so he could quietly divide the section on the third monarchy into separate volumes on each of the Northern kingdoms.

And in order to avoid the dizzying complexities of a straight narrative presentation of hundreds of years of documented history, he followed Renaissance historian Paolo Emilio – who wrote on France – in adopting the Suetonian model of a series of biographies.

In 1710, together with Scipione Maffei, Antonio Vallisneri and his brother, Pier Caterino Zeno, he founded the Giornale de' letterati d'Italia, maintaining that it was necessary that "Italians themselves make their own newspaper... revealing that good sense, erudition and ingenuity never were lacking among us, and now more than ever are they flourishing."

When Apostolo Zeno was called to duty as poet laureate to the imperial court of Vienna in 1718, his brother, Pier Caterino took over the direction until 1732, publishing the periodical annually.

Zeno wrote the libretti for 36 operas with historical and mythological themes, including Gli inganni felici (1695), Odoardo (1695) Faramondo (1698), Lucio Vero, Imperatore di Roma (1700), Griselda (1701), Temistocle (1701), Merope (1711, Edition, 1727), L'Ambleto (1712), Alessandro Severo (1716), T'Euzzone (1719), Ormisda (1721), Artaserse (1724), Semiramide (1725), Domenico Sarro's Il Valdemaro (1726), Astarto (1730), Caio Fabbricio (1733), Euristeo (published 1757), and Sesostri re d'Egitto (Prague edition 1760) as well as 17 oratorios, including Giuseppe (1722), Gioaz (1726), David umiliato (1731).