His opera Didone abbandonata, premiered on 1 February 1724 at the Teatro San Bartolomeo in Naples, was the first setting of a major libretto by Pietro Metastasio.
He is best remembered today as the composer of Achille in Sciro, the opera that was chosen to open the new Teatro di San Carlo in 1737.
In recent years it was performed in the State Theatre of Stuttgart, the Bochum Symphony as well as the Semperoper Dresden.
In addition to his Operas and other large scale works, Sarro has written a considerable number of vocal cantatas which show great charm and inventiveness.
The only known depiction of Domenico Sarro is Nicolò Maria Rossi's painting of the Viceroy at the festa of the Quattro Altari in the Harrach collection, Sarro is one of the many composers depicted as part of the Neapolitan Court (La festa dei Quattro Altari, 1745)