The Via Appia, which was called longarum Regina viarum (i.e. "queen of the long roads") by Caecilius Statius, was built centuries after, in 312 BC.

The Roman heritage in the area is proved by a system of sumptuous patrician villas, a network of irrigation ditches, factories and defensive buildings, such as the Aurelian Walls.

To the east, Appio-Latino borders with Quartiere Tuscolano (Q. VIII), from which it is separated by the stretch of Via Appia Nuova between Porta San Giovanni and Via dell'Almone.

The quarter includes the area traditionally known as L'Alberone, which is located on the right side of Via Appia Nuova, among the railway, the park of Villa Lazzaroni and Via Latina.

It hit the headlines in 1969, when the inhabitants, longing for more respectable housing conditions, occupied some buildings of a big real estate company in the rione Esquilino.