Both episodes followed a unified storyline of a bombing at Chicago Medical Center and the search and rescue of survivors as well as the investigation of those responsible.

Boden informs Hermann that he will be acting lieutenant on Truck 81 for the day because Casey and Gabby are volunteering for a charity race event at Chicago Medical.

Doctors begin treating Burgess's niece who sustained a crushed liver and is bleeding internally as a result of the explosion.

Whelan's sister, who initially seemed to only have a minor concussion, has a seizure and is diagnosed with a subdural hematoma; as a result she is also rushed into surgery.

The doctor finds a liver that was initially planned for a Syrian ambassador to the United States and prepares for the transplant but the organ was damaged in the explosion.

Voight, Lindsay, Antonio, and Halstead of the Chicago Police Department's intelligence unit as well as Illinois State Police, Federal Bureau of Investigation, Department of Homeland Security, Bureau of Alcohol, Tobacco, Firearms and Explosives, and the Central Intelligence Agency arrive to begin investigating the bombing.

Jin is shown to the secondary car bomb to analyze it while the rest of intelligence including Ruzek, Olinsky, and Sumner begin interviewing witnesses.

Jin pulls a print off of the second bomb and acquires a no-knock warrant to search the suspect's apartment.

Intelligence attempts to intercept him but the situation escalates when he holds Lindsay hostage at knifepoint; the scene is quickly diffused by Mills.

A doctor approaches Whelan's parents about donating the liver of their daughter, who has been declared brain dead, to Burgess's niece.

Olinsky spots Ted on the roof of a building adjacent police headquarters and Lindsay and Halstead go after him, but he takes a hostage and runs.

Intelligence engages in a shootout with Ted but ultimately take him into custody after Voight personally wounds him for endangering his city.

[2] Wolf stated "As our country has gone through tragedies like that one, it's the first responders who always set the tone and who always begin to put us back together, and I want to really examine that now that we've got these two shows with the fire fighters and the police.

[11] Matt Carter with CarterMatt reviewed both parts of the crossover stating that the Fire episode was something normally seen in a season finale and that it was terrible and triumphant at the same time.