[2] The grand opening of Chicago Med's emergency department is interrupted by victims of an "L" train crash, pushing the staff to their limits.

Dr. Will Halstead and the new trauma fellow Dr. Connor Rhodes butt heads when the latter pulls rank when it comes to treating patients.

Dr. Choi, Dr. Charles, and Detective Jay Halstead investigate a woman from a Firehouse 51 call who was admitted after a possible suicide attempt.

[24] In July 2015, Brian Tee joined the cast as Dr. Ethan Choi, an expert in infectious disease prevention and a Navy Reserve medical officer.

[25] Pretty Little Liars star Torrey DeVitto was cast on August 13, 2015, as Dr. Natalie Manning, the ED pediatrician.