[3] The high school was dedicated on September 2, 1928, in honor of Thomas Aquinas by Bishop Alexander Joseph McGavick of the Diocese of La Crosse.

The high school was originally staffed by diocesan clergy and the Franciscan Sisters of Perpetual Adoration.

In 1997, the Bishop Burke Hall addition to Aquinas High School was dedicated in honor of Bishop Raymond Leo Burke, now the Prefect of the Apostolic Signatura in the Vatican City and a former religion teacher at Aquinas High School.

[4] The Aquinas High School crest, designed in 1942, first appeared in the yearbook, the Trumpet, and on the 1943 class rings.

[4] The school competes in the Mississippi Valley Conference and the WIAA with baseball, basketball, cross country, dance, football, golf, gymnastics, skiing, soccer, softball, swimming, tennis, track and field, volleyball, and wrestling teams.