The stable climate in ar-Ramtha and its surrounding areas attracted many animals to live in neighborhood of ar-Ramtha, as well the simple conditions for managing a stable long life there attracted humans to make those regions their earliest choices to gather in groups of hunters and to live in rocky caves.

Artifacts and graves in the area show that ar-Ramtha has been inhabited at least since the Bronze Age, but the lack of study of the region gives us no exact information about when humans had selected the land for living.

During the spread of Islam, ar-Ramtha, which was in the Hauran territory, was a port for Muslim scholars crossing between Syria and the Hejaz.

[citation needed] In 1596 it appeared in the Ottoman tax registers under the name of Ramta, being part of the nahiya of Butayna in the Qadaa Hauran.

They paid a fixed tax-rate of 40% on agricultural products, including wheat, barley, summer crops, goats and bee-hives; a total of 2,740 akçe.

Due to its location, Ramtha played a significant role in helping refugees fleeing the Syrian Civil War to Jordan.

The Al Hassan industrial estate houses several outsourcing companies supported by foreign shareholders with most of the products sold to American and European markets.

These goods were imported by so-called "bahhara" (sailors), Jordanian drivers permitted to enter Syria.