The Seminary is situated in the historic center of Palermo, facing the magnificent post office building, between a street of the same name (Via Seminario Italo-Albanese) and Piazza Padre Giorgio Guzzetta.

Since 1950, due to significant damage caused by American bombings of Palermo during World War II, its headquarters officially relocated to Piana degli Albanesi.

During the pontificate of Pope Clement XI (1700–1721), of Albanian origin, and Clement XII (1730–1740), there was a renewed interest from the Holy See in the Byzantine Christian tradition, which manifested in the founding of the "Collegio Corsini" of Saint Benedict (San Benedetto Ullano, 1732) in Kozenxë (later transferred in 1794 to Saint Demetrius of Coronë, known as "Collegio San Adriano" for the Arbëresh communities of the Byzantine rite in Calabria), and the establishment of the Arbëresh Seminary of Palermo (1734) for the communities of Sicily.

The Seminary thus became the most important religious and cultural center for the education - according to the Eastern Byzantine rite - of young generations of Arbëresh priests for their colonies in Sicily.

He was succeeded by the priest Papa Pjetër d'Andrea from Himara, who in 1746 was appointed chaplain of the parish church of the Seminary of "Shën Kollit" (San Nicolò "dei Greci"), until his death on October 17 of the same year.