[1] The then Governor Dejazmach Aemro Selassie Abebe selected a suitable place for construction of the hospital to serve the population from the two sub-cities.

The Ethiopian Ministry of Health, Angelina Roberto and Kebede Mulat General Contractors made a contractual agreement to build the hospital.

[1] The machine was introduced by a Norwegian medical doctor named Torvid Kiserude, who has worked in Arba Minch hospital for 8 years.

[citation needed] According to an Ethiopian health system model, a general hospital should serve 1-1.5 million population with an average of 234 staffs.

In the early days, the hospital collaborated with the Catholic mission and the Gamo-Gofa Province women's association on the construction of the “Mothers’ Village”.

This was a place where mothers coming from different woreda (district) and awrajas (Zones) stay and get treatment for 1 birr per day until they deliver their baby.

[1] An integrated laboratory and outpatient department was built in February 2012 by the President's Emergency Plan for AIDS Relief (PEPFAR).

[9] A recent collaboration was made between a European non-governmental organization called DNDi (Drug for Neglected Diseases initiative), Addis Ababa University, the Ministry of Health and Arabaminch hospital to establish Leishmaniasis examination and treatment centre.

Some of the researches that have been done in Arbaminch Hospital targeting children include assessment of neonatal and child mortality[14] and diarrheal diseases.

[16][17] The support of the NLM on HIV/AIDS made it possible to conduct various studies on HIV patients, treatment and co-morbidities in Arba Minch Hospital.

Other researches focusing on the prevalence of different diseases or opportunistic infections[21][22] and nutritional status[citation needed] of HIV patients were also studied.