Archeologists have discovered evidence of the earliest known inhabitants of the Venezuelan area in the form of leaf-shaped flake tools, together with chopping and plano–convex scraping implements exposed on the high riverine terraces of the Pedregal River in western Venezuela.
[1] Late Pleistocene hunting artifacts, including spear tips, come from a similar site in northwestern Venezuela known as El Jobo.
Known to the locals as mene, the thick, black liquid was primarily used for medicinal purposes, as an illumination source, and for the caulking of canoes.
[5] In the 16th century when Spanish colonization began in Venezuelan territory, the population of several indigenous peoples such as the Mariches (descendants of the Caribes) declined.
Native caciques (leaders) such as Guaicaipuro (c. 1530–1568) and Tamanaco (died 1573) attempted to resist Spanish incursions, but the newcomers ultimately subdued them.