Architrypethelium barrerae is a species of corticolous (bark-dwelling) and crustose lichen in the family Trypetheliaceae.

The type specimen was collected in the El Haya ecological park (Xalapa, Veracruz).

The specific epithet honours Dr. Clementina Barrera-Bernal, who supported Guzmán-Guillermo's studies.

[1] Architrypethelium barrerae has a thin green to yellowish thallus, with ascomata immersed in the bark substrate, opened by small holes (ostioles) measuring 0.7–1.2 mm in diameter.

The lichen contains two secondary compounds (detectable using thin-layer chromatography), an unidentified anthraquinone, and lichexanthone.