The cathedral however lost the relics of Donatus, which were transferred to the church of San Donato in Castiglione Messer Raimondo (in what is now the province of Teramo).
The interior has a nave and two aisles divided by piers with ogival arches, with five spans covered by cross vaulting, without a transept.
The seven stained glass windows in the south aisles were executed in 1516-1524 by Guillaume de Marcillat, who also painted frescos of biblical scenes on the ceiling.
The Chapel of the Madonna del Confort is a Neoclassicist work, built from 1796 and housing several terracottas by Andrea della Robbia.
Another funerary monument in the aisles is that of Ciuto Tarlati (1334), formed by a marble sarcophagus of the 4th century AD and a series of reliefs by Agostino di Giovanni, crowned by a 14th-century fresco.