Until 1938, it was also the terminus of a light metre-gauge railway line (Le Blanc - Argenton-sur-Creuse via Saint-Benoît-du-Sault), which opened in 1904.

The destructed wagons chaotically piled up in the Saint-Paul bridge cutting and the train's food product load spread as far as the rue Gambetta.

[2] On the morning of June 9, 1944, the train station became the location of a skirmish between a German military detachment and a group of French Resistance fighters led by Colonel Roland Despains.

At the regional level, Argenton-sur-Creuse is served by TER Centre-Val de Loire[5] trains operating between Orléans, Vierzon, Châteauroux and Limoges.

A committee for defence of the station was created in April 2018 in order to preserve the number of services and to demand the restoration of stops deleted from the Intercités timetables in July 2017.

[13] The committee's president met with French Transport Minister Élisabeth Borne during her visit to Châteauroux on July 15, 2019.

[14] Among other modes of activism, the committee protests by interrupting the flow of trains in order to demand additional Intercité services which would allow at least one return journey a day to both Paris and Limoges.