Closed to most traffic, this section forms a taxi and bus corridor for services travelling to the east and south-east of the city.

After crossing the junction with Union Street / Jamaica Street, it passes underneath the expanse of railway lines at Glasgow Central Station (the so-called Hielanman's Umbrella)[1] before becoming a major thoroughfare (A814) connecting the city centre to the M8 motorway and the Clydeside Expressway running alongside the River Clyde; however while traffic continues freely on the expressway, Argyle Street itself, which ran north-west through Anderston until the redevelopment of the area in the 1960s, now terminates as a through road after passing under the motorway at Anderston railway station, instead existing as an address in two unconnected sections.

The route then joins St. Vincent Street at Finnieston/Sandyford and is revived as a major thoroughfare as it heads out towards the West End of the city.

It was renamed in honour of the Duke of Argyll, some time after the removal of the West Port in 1751, as a result of the expansion of the city westward.

[3] Major reconstruction of the area at the turn of the 1970s which saw the construction of the Glasgow Inner Ring Road, the demolition of Anderston Cross and its replacement with the Anderston Centre complex changed the line of Argyle Street, the eastern half now terminating underneath the Kingston Bridge approach viaduct whilst the main vehicle route over the motorway runs along St. Vincent Street, leaving a 250-metre stretch of the western half of road in Anderston isolated as a cul de sac.