Isotrema fangchi (Y.C.Wu ex L.D.Chow & S.M.Hwang) X.X.Zhu, S.Liao & J.S.Ma Aristolochia fangchi (Chinese: 广防已 guang fang ji), is a species of flowering plant in the family Aristolochiaceae, native to Vietnam and southeast and south-central China.

[1] In 1993, a series of end-stage renal disease cases were reported from Belgium associated with a weight loss treatment, where Stephania tetrandra (Chinese: 粉防己 fen fang ji) in a herbal preparation was accidentally substituted with Aristolochia fangchi.

[2][3] More than 105 patients were identified with nephropathy following the ingestion of this preparation from the same clinic from 1990 to 1992.

Many required renal transplantation or dialysis.

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