The western terminus of Route 82 is located at its junction with Business Loop 19 (Grand Avenue) in Nogales and its eastern terminus at its junction with State Route 80 just north of Tombstone.
Other than the aforementioned locations, Route 82 also travels through Sonoita and Whetstone, and is one of the few major east–west highways in its service area.
Passing several riverbeds, the route skirts the northwest side of Nogales International Airport before turning north.
The highway, which provides access to Patagonia Lake State Park, briefly enters Coronado National Forest before turning northeast again and following the Sonoita Creek.
SR 82 passes through the town of Patagonia and heads through a gap between two sections of the Coronado National Forest, following an abandoned rail line.