The Interstate Highways in Arizona are the segments of the Dwight D. Eisenhower System of Interstate and Defense Highways that are owned and maintained by the U.S. state of Arizona, totaling about 1,169 miles (1,881 km).

The only auxiliary Interstate that has existed in Arizona was I-410, which was an inner loop route in Phoenix.

The longest Interstate in Arizona is I-10, which spans 392.33 miles (631.39 km)[1] across southern and central Arizona, and the shortest Interstate is I-15, which only traverses the northwestern corner of the state, running from Nevada to Utah, spanning only 29.39 miles (47.30 km).

I-11 is a proposed Interstate that is currently in its planning phase and is expected to run from the Hoover Dam to Nogales.

[11] For example, all currently state designated I-10 Business Loops in Arizona are referred to as "SB010" which is the Arizona Transportation Information System (ATIS) code for "State Business Route 10" or "SR 10B" for short.