106) is an east–west state highway in Independence County.

The highway runs south past the Batesville Livestock and Forestry Research Station, a branch of the University of Arkansas System Division of Agriculture.

The parent route turns east at this point, passing a quarry and Ruddle Hill before entering the Batesville city limits and terminating at Highway 69B.

[1] The route begins at Highway 106 and runs west to Bethesda, a small unincorporated community.

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