One segment of 16.71 miles (26.89 km) runs east from U.S. Route 65 (US 65) at Botkinburg to Highway 9/Highway 16 near Shirley.

[4] A third segment of 20.43 miles (32.88 km) begins at the Sugar Maple Dr/Old Tr intersection outside Heber Springs and runs east to Highway 16 in Pangburn.

The highway runs southeast through an undeveloped part of the small town to Shiloh Park on Greers Ferry Lake.

[4] State maintenance ends at the shore of the lake, where the highway formerly continued south to Heber Springs prior to the damming of the Little Red River in 1962.

Olmstead & Son Funeral Home, Cleburne County Courthouse, all listed on the NRHP.

[8] Highway 110 was rerouted onto a new alignment in July 1958, crossing the river at a new location and continuing east to Wilburn.