From Conway, the road runs north to Wooster, where it turns northeast, meeting US 65 in Greenbrier.

Major towns along the road include Walnut Ridge and Paragould.

This section through the cotton country of eastern Arkansas was flat and largely straight, except where it passed through Crowley's Ridge west of Paragould.

Some sources continue to claim that Highway 25 ends at US 67/Highway 34 at Walnut Ridge.

Though this was the original west end of US 412 when established in 1982 from Highway 25 east of Walnut Ridge, it was later extended west across Arkansas along the former Black Rock-Walnut Ridge segment of Highway 25 (including its concurrency with US 63 from Black Rock to Portia), thus truncating Highway 25 at Black Rock where it meets the present US 63/US 412 concurrency.