A second route of 20.50 miles (32.99 km) begins at US 165 near Jerome and runs east through Lake Village to a levee near the Mississippi River.

The route runs east through agricultural land, becoming a section line road shortly before terminating at US 165/AR 1/GRR south of Gillett.

[6] The route crosses flat agriculture and aquaculture operations, intersecting Highway 293 in western Chicot County.

Highway 144 breaks east from the concurrency toward downtown Lake Village at a junction with US 82, with US 65/US 82/US 278 continuing south toward Louisiana and Mississippi.

[1][2] The route was extended east along former US 82 to Leland landing, the main ferry crossing on the Mississippi River in the area, on the 1940 state highway map.