[4] The city is located on the Arkansas Grand Prairie, known for rice farming and duck hunting.

Within the Delta, Arkansas County is almost entirely within the Grand Prairie subregion, historically a flat grassland plain underlain by an impermeable clay layer (the Stuttgart soil series).

Prior to the 19th century, flatter areas with slowly to very slowly permeable soils (often containing fragipans) supported Arkansas's largest prairie, covered in prairie grasses and forbs, with oaks covering the low hills and ridges, and pockets of floodplains with bottomland hardwood forests.

This region was a sharp contrast to the bottomland forests that once dominated other parts of the Mississippi Alluvial Plain.

Distinctively, rice is the main crop; soybeans, cotton, corn, and wheat are also grown.

The rice fields provide habitat and forage for large numbers and many species of waterfowl; duck and goose hunting occurs at this important spot along the Mississippi Flyway.

[7] According to the United States Census Bureau, the city has a total area of 2.6 square miles (6.7 km2), all land.

As of the 2020 United States census, there were 3,056 people, 1,226 households, and 730 families residing in the city.

The movie featured a scene filmed at DeWitt Hospital & Nursing Home.

Perhaps the most popular annual event in DeWitt is duck hunting season between November and January, a tradition dating back to the Illinois Indians who traveled south to Arkansas to hunt, popular with Arkansans and tourist hunters from across the country.

AR 980 gives access to the DeWitt Municipal Airport, a general aviation facility.