The eastern half of the route runs through the Lower Arkansas Delta, serving small towns and agricultural areas.

Running east as 7th Street (the westbound half of the couplet is Dr. Martin Luther King Jr. Blvd), the road enters Arkansas at an intersection with State Line Avenue.

At Hazel Street, US 67/US 82 intersects US 59/US 71, beginning a brief concurrency east to Hickory St, when US 59/US 71 turns south toward Shreveport, LA.

[5] After passing over Dorcheat Bayou, US 82 serves as the northern terminus of Highway 344 near Lake Columbia.

On the eastern side of the city, US 82 intersects and overlaps US 79 for 2.20 miles (3.54 km)[1] until a junction with US 82B (Main Street).

US 82B runs west toward downtown Magnolia, US 79 continues south to Haynesville, Louisiana, and US 82 turns east as a section line road toward El Dorado.

In the city's southeast corner, an interchange with US 167, US 63, and Highway 7 gives access to Camden, Hampton, and Bernice, LA.

Upon entering the city, US 82/US 425 begins overlaps with Highway 52, passing the First United Methodist Church and Hamburg Commercial Historic District.

The route runs northeast to Thebes, where it has a junction with Highway 160 before bypassing Montrose, where US 82B serves the downtown business district.

This act authorized governor Bill Clinton to sign a compact with Texas, Mississippi, and Alabama to four-lane US 82 across the four states.

[13] However, it appears the Authority was never created; with Texas, Alabama, and United States Congress coordination and approval never coming to pass.