One route of 5.9 miles (9.5 km) runs north from the Jacksonville city limits near Interstate 440 (I-440) to I-57 near the Little Rock Air Force Base.

The rationale behind this legislation is not recorded in the minutes of the Arkansas State Highway Commission (ASHC) meeting, but the ASHC concurred with the General Assembly and removed the highway segment from the system on May 13, 1959.

[3] The ASHC closed a gap of 7.99 miles (12.86 km) along the Lonoke County segment of Highway 161 on December 13, 1972.

[4] A segment between Cabot and El Paso was redesignated as Highway 5 on June 24, 1970.

[5] The Arkansas State Highway Commission marked the segment between US 70 and the Jacksonville city limits for removal from the state highway system on December 9, 2021 following construction of a pavement improvement project along the route.