[1] The route passes through several cities and towns, including Hope, Benton, Little Rock, Jacksonville, Cabot, Beebe, Walnut Ridge, and Pocahontas.

Shortly thereafter, US 67 separates from US 82 and travels to the northeast along Broad Street, crossing Interstate 49 (I-49) and passing Texarkana Regional Airport.

Money for road maintenance was raised individually by county in the early 20th century, which hindered development of the route.

In early 2009, the Arkansas legislature passed a bill naming the portion of US-67 from the Missouri state line to Jackson County "Rock n' Roll U.S. 67" as a tribute to the route that many musicians of the 1950s and 1960s took as they traveled.

Governor Mike Beebe stated that he had hopes that the naming would bring tourism to northeast Arkansas.

Several portions of the original late 1920s alignment of US 67 have survived, some of which are listed on the National Register of Historic Places.

One listed segment is in Lawrence County, which is about 11.25 miles (18.11 km) in length, and runs north from Alicia to Hoxie, most of this being sandwiched between the present Arkansas Highway 367 and US 67, and the adjacent railroad tracks.

[9] Listed on the NRHP as Old US 67, Mandeville, a historic roadway section of US 67 is preserved in Miller County, Arkansas.