The route begins at Highway 289 and runs north 39.07 miles (62.88 km) to Wirth.

Cherokee Village is a planned retirement community by John A. Cooper, a forerunner to Bella Vista and Hot Springs Village, which also include a series of winding roads, cul-de-sacs, golf courses, and other retirement amenities.

[5] While passing through the city, US 62/US 412/AR 175 begin an overlap with US 63, which continues east until Highway 175 splits north from the concurrency.

Highway 175 runs north through a sparsely populated rural area toward Missouri.

The highway runs northeasterly to the community of Sellers' Store before turning north along a section line road to terminate at Wirth.