The route continues to head east into the Northwest Arkansas metropolitan area, mainly traveling through the city of Springdale.

[2] During this time, the routes intersect several communities and many highways along the way, traveling through the cities of Harrison, Yellville, Mountain Home, and Cherokee Village.

Both routes also share a concurrency with US 65 for about 12.2 miles (19.6 km), beginning north of Harrison, and ending in Bellefonte.

The route began at OK 33 at the Oklahoma state line near Siloam Springs (now US 412), and ended at US 62 in Alpena.

The senators' stated reasons for seeking an Interstate designation along US-412 included encouraging economic development, expanding opportunities for employment in the region, making travel safer and shipping easier, attracting new businesses, and better connecting rural and urban communities.

Other supporters of the measure include the mayor of Tulsa, G. T. Bynum, and the heads of both ArDOT and the Oklahoma Department of Transportation (ODOT).