The route runs towards the northeast for about 9.5 miles (15.3 km) before intersecting AR 73 in Cross Roads.

The route continues northwest for about 4.4 miles (7.1 km) before reaching its northern terminus at US 278 in Washington.

The route heads almost directly north for about 6.8 miles (10.9 km) before reaching its northern terminus at US 371 just east of Blevins.

The route heads mainly towards the east, before turning towards the north shortly before crossing the Little Missouri River.

Shortly after, the route intersects AR 301 just south of Pisgah, which provides direct access to the Crater of Diamonds State Park.