An eastern alignment runs 18.59 miles (29.92 km) from US 67 in east Hope to Arkansas Highway 53.

Highway 73 runs along the southern border of the Rick Evans Grandview Prairie Wildlife Management Area past the Grandison D. Royston House before intersecting Highway 195 at Cross Roads.

The route is a low traffic road with less than 1000 vehicles per day (VPD) from its western terminus to the junction with Highway 195.

East of the intersection the Average daily traffic (ADT) increases to about 1300 VPD (as of 2010).

[1] The route begins with an average of 2400 vehicles per day from US 67 in Hope to the intersection with Lake Shore Street, which provides access to William Jefferson Clinton Primary School (as of 2010).