The southern segment of 7.89 miles (12.70 km) runs from Oklahoma State Highway 101 near Uniontown to AR 59.

[3] The route is not paved within Devil's Den State Park, and was the only Arkansas state highway that remains unpaved until a January 2016 announcement that paving would begin.

AR 220 begins at SH 101 at the Oklahoma state line and runs as the Uniontown Highway to meet AR 59 south of Cedarville.

The route begins again 4 miles (6.4 km) north, when the route turns northeast, ending at AR 170 in Devil's Den State Park.

Media related to Arkansas Highway 220 at Wikimedia Commons