[3] The route runs north to enter Van Buren, crossing I-540 and briefly concurring with US 64.

North of Cedarville, AR 59 curves west toward Oklahoma, coming within 0.1 miles (0.16 km) of the border.

[2] Entering Washington County, the route meets Arkansas Highway 156 in Evansville and AR 244 in Tolu.

Upon entering Benton County, AR 59 concurs with US 412 east around the southeast edge of Siloam Springs.

The highway runs further north to Wee Pine Knot, the Adar House, and Butler Creek Cemetery in Sulphur Springs.