One route of 4.50 miles (7.24 km) begins at County Road 534 (CR 534) at Clover Bend and runs east to Highway 367 in Minturn.

Highway 228 begins state maintenance at Lawrence County Road 534.

It runs east through the Clover Bend Historic District to Minturn, where it ends at US 67.

The route runs northeast, serving as the northern terminus of Highway 349 before entering Sedgwick where it meets US 63.

Highway 228 overlaps US 63 briefly before turning northeast into Greene County.