Passing through a residential area on the outskirts of Jonesboro, the route ends at a junction with Highway 18/Highway 91 at the campus of Westside Consolidated School District near Herman.

Although Highway 349 has proximity to US 49, the first segment was designated in November 1966,[1] prior to US 49 entering the area in 1978.

[5] The Lawrence County segment was created following the Arkansas General Assembly passing Act 9 of 1973.

[6] In 1977, the southern terminus was extended to Highway 39 (which would be redesignated as US 49 the following year[5]) at Gibson.

[7] In 1979, this mileage was removed from the state highway system in a deal between the Craighead County Judge and the AHTD.