One segment of 18.6 miles (29.9 km) runs from the Oklahoma state line east to U.S. Route 71 (US 71) in Lockesburg.

The two sections were formerly connected, but a middle segment of 53 miles (85 km) between Lockesburg and Prescott was redesignated as US 371 in 1994.

The route begins at the Oklahoma state line as a continuation of Panki Bok Road and runs east to Horatio.

The route also meets Highway 368, which leads to the Poison Springs Wildlife Management Area.

The route continues east past the Richmond-Tufts House and Harvey's Grocery and Texaco Station and terminates at US 278 west of Camden.