One segment of 5.50 miles (8.85 km) runs from Ozark National Forest at Brannon north to Highway 16 at Crosses.

[3] A second segment of 3.07 miles (4.94 km) runs northeast from Combs until it continues as Madison County Road 4554 (CR 4554).

[3] The third segment runs 4.71 miles (7.58 km) north as a continuation of CR 5395 at Japton through Georgetown to Highway 74 at Drake's Creek.

[3] The route runs north from County Road 4035 at Brannon in the Ozark National Forest to Highway 16 at Crosses, where it terminates.

[3] Running a total distance of approximately 2.2 miles (3.5 km),[4] the spur followed part of the 1920s–1940's alignment of AR 68 (now U.S. Route 412).