The longest and most well-known segment of 54.19 miles (87.21 km) runs from Highway 28 in Plainview east to U.S. Route 65B (US 65B) in Conway.

[5] A fifth route of 2.34 miles (3.77 km) begins at Highway 282 near Rudy and runs north to County Road 23 (CR 23).

[5] The route runs north from Highway 282 at Rudy to terminate at Crawford County Road 23.

[2] The route runs east from the Sebastian County line to Highway 10 west of Booneville.

[6] The route then intersects Highway 7 and runs parallel with the Fourche La Fave River and passes through Nimrod.

It runs east for another 10.1 miles (16.3 km) until it intersects the northern terminus of Highway 155.