One segment of 38.38 miles (61.77 km) runs from the Texas state line north to U.S. Route 70B (US 70B) in De Queen.

Highway 41 continues northeast into Sevier County before passing the Pond Creek National Wildlife Refuge.

[1] The original route was established between De Queen and Texas and has remained largely unchanged.

[7] The Highway 41 designation was extended to the current northern terminus at Citadel Bluff Park on September 25, 1968.

[9] A similar realignment took place in De Queen in 1980; with Highway 41 being rerouted away from the historic city center to a newly constructed roadway.

[10] It was deleted on February 19, 1992 by the Arkansas State Highway Commission at the request of the Mayor of De Queen, with the city accepting maintenance responsibilities.